Recent research shows Green tea extract reverses vascular dysfunction in patients with coronary artery disease in humans.
In the first study, researchers sought an explanation for why previous research has shown that the green tea component epigallocatechin gallate (EGCG) can support the health of the heart.
In the double blind, placebo-controlled, crossover design trial, the researchers studied 42 subjects randomly assigned to receive either an epigallocatechin gallate supplement or a placebo. Before the subjects crossed-over to the other intervention, they underwent a one-week washout where they consumed neither the placebo nor the epigallocatechin gallate.
Researchers then measured brachial artery flow-mediated dilation (FMD) in the arm, which is an indicator of how well blood is flowing through vessels. The researchers measured flow-mediated dilation through a vascular ultrasound at baseline, again two hours after subjects received an initial dose of EGCG (300 mg) or placebo, and after two weeks of supplementation with EGCG (two 150 mg doses per day) or a placebo.
Supplementation with the green tea extract improved flow-mediated dilation from 7.1 to 8.6 percent two hours after the initial 300 milligram dose. In addition, blood levels of EGCG correlated with improved vascular function. Placebo treatment had no significant effect.
The study authors concluded, “epigallocatechin gallate acutely improves endothelial function in humans with coronary artery disease, and may account for a portion of the beneficial effects of flavonoid-rich food on endothelial function.”
[seems polyphenols in flavonoid rich foods are implicated yet again in improving cardio-vascular health, still prefer to get mine from red wine & dark chocolate though.]
(a word of caution, this research published by VRP (vitamin research products) who incidentally produce “Green Tea Extract”.)
Widlansky ME, Hamburg NM, Anter E, Holbrook M, Kahn DF, Elliott JG, Keaney JF Jr, Vita JA. Acute EGCG Supplementation Reverses Endothelial Dysfunction in Patients with Coronary Artery Disease. J Am Coll Nutr. 2007 Apr 26 (2):95-102